Multiple-Sequence Information Provides Protection against Mis-Specified Potential Energy Functions in the Lattice Model of Proteins

Yan Cui; Wing Hung Wong

doi:10.1103/PhysRevLett.85.5242

Multiple-Sequence Information Provides Protection against Mis-Specified Potential Energy Functions in the Lattice Model of Proteins

Yan Cui and Wing Hung Wong

Phys. Rev. Lett. 85, 5242 – Published 11 December 2000

Abstract

The neutral nets in the lattice models of proteins are composed of a group of similar sequences that encode for the same native structure. The maximal neutral nets in an $HP$ and an $AB$ lattice model are investigated by exhaustive enumeration in the conformation space. The result demonstrates that the performance of mis-specified potential functions can be improved significantly by averaging over sequences in the neutral nets.

Received 10 March 2000

DOI:https://doi.org/10.1103/PhysRevLett.85.5242

Authors & Affiliations

Yan Cui^1,2 and Wing Hung Wong^1,2,3,*

¹Department of Biostatistics, Harvard University, Boston, Massachusetts 02115
²Dana-Farber Cancer Institute, Boston, Massachusetts 02115
³Department of Statistics, Harvard University, Cambridge, Massachusetts 02138

^*To whom correspondence should be addressed. Present address: Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115.Email address: wwong@hsph.harvard.edu