Phase Transition and Phase Segregation in a Single Double-Stranded DNA Molecule

Masanori Ueda and Kenichi Yoshikawa
Phys. Rev. Lett. 77, 2133 – Published 2 September 1996
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Abstract

From the single-molecule observation of a long DNA chain, T4 DNA (166 kbp), by fluorescence microscopy, we found that an individual chain exhibits a first-order phase transition between an elongated coil and a compact globule with a change in the concentration of alcohol added to the aqueous environment. In the globule phase near the transition point, a metastable state is observed in which the globular and coil states coexist within a single DNA chain, i.e., phase separation is induced along a single chain.

  • Received 16 October 1995

DOI:https://doi.org/10.1103/PhysRevLett.77.2133

©1996 American Physical Society

Authors & Affiliations

Masanori Ueda and Kenichi Yoshikawa

  • Graduate School of Human Informatics, University of Nagoya, Nagoya 464-01, Japan

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Vol. 77, Iss. 10 — 2 September 1996

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