Abstract
Using path integrals, the statistics of kinetic pathways on a biased random energy landscape can be mapped on to the statistical mechanics of the random directed polymer. Using this, we make explicit the role of time scales in defining a protein folding pathway and the connections between thermodynamic glass transitions of the protein and the emergence of discrete kinetic pathways for folding.
- Received 30 October 1995
DOI:https://doi.org/10.1103/PhysRevLett.76.4861
©1996 American Physical Society