RNA Virus Evolution via a Fitness-Space Model

Lev S. Tsimring, Herbert Levine, and David A. Kessler
Phys. Rev. Lett. 76, 4440 – Published 3 June 1996
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Abstract

We present a mean-field theory for the evolution of RNA virus populations. The theory operates with a distribution of the population in a one-dimensional fitness space, and is valid for sufficiently smooth fitness landscapes. Our approach explains naturally the recent experimental observation [I. S. Novella et al., Proc. Natl. Acad. Sci. U.S.A. 92, 5841–5844 (1995)] of two distinct stages in the growth of virus fitness.

  • Received 16 January 1996

DOI:https://doi.org/10.1103/PhysRevLett.76.4440

©1996 American Physical Society

Authors & Affiliations

Lev S. Tsimring and Herbert Levine

  • Institute for Nonlinear Science, University of California, San Diego, La Jolla, California 92093-0402

David A. Kessler

  • Department of Physics, Bar-Ilan University, Ramat Gan 52900, Israel

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Vol. 76, Iss. 23 — 3 June 1996

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