Simulation of biological cell sorting using a two-dimensional extended Potts model

François Graner and James A. Glazier
Phys. Rev. Lett. 69, 2013 – Published 28 September 1992
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Abstract

We simulate the sorting of a mixture of two types of biological cells using a modified version of the large-Q Potts model with differential adhesivity. We find long-distance cell movement leading to sorting with a logarithmic increase in the length scale of homogeneous clusters. Sorted clusters then round. We find two successive phases: A rapid boundary-driven creation of a low-cohesivity cell monolayer around the aggregate, and a slower boundary-independent internal rearrangement.

  • Received 16 March 1992

DOI:https://doi.org/10.1103/PhysRevLett.69.2013

©1992 American Physical Society

Authors & Affiliations

François Graner and James A. Glazier

  • Research Institute for Electrical Communications, Tohoku University, 2-1-1 Katahira, Sendai 980, Japan

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Vol. 69, Iss. 13 — 28 September 1992

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