• Open Access

Kinetic Selection of Template Polymer with Complex Sequences

Yoshiya J. Matsubara and Kunihiko Kaneko
Phys. Rev. Lett. 121, 118101 – Published 11 September 2018
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Abstract

The emergence and maintenance of polymers with complex sequences pose a major question in the study of the origin of life. To answer this, we study a model polymerization reaction, where polymers are synthesized by stepwise ligation from two types of monomers, catalyzed by a long polymer as a template. Direct stochastic simulation and dynamical systems analysis reveal that the most dominant polymer sequence in a population successively changes, depending on the flow rate of monomers to the system, with more complex sequences selected at a lower flow rate. We discuss the relevance of this kinetic sequence selection through nonequilibrium flow to the origin of complex polymers.

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  • Received 29 March 2018
  • Revised 21 June 2018

DOI:https://doi.org/10.1103/PhysRevLett.121.118101

Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.

Published by the American Physical Society

Physics Subject Headings (PhySH)

Physics of Living Systems

Authors & Affiliations

Yoshiya J. Matsubara* and Kunihiko Kaneko

  • Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan

  • *yoshi@copmlex.c.u-tokyo.ac.jp
  • kaneko@complex.c.u-tokyo.ac.jp

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Issue

Vol. 121, Iss. 11 — 14 September 2018

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