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Propagating Stress Waves During Epithelial Expansion

Shiladitya Banerjee, Kazage J. C. Utuje, and M. Cristina Marchetti
Phys. Rev. Lett. 114, 228101 – Published 2 June 2015
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Abstract

Coordinated motion of cell monolayers during epithelial wound healing and tissue morphogenesis involves mechanical stress generation. Here we propose a model for the dynamics of epithelial expansion that couples mechanical deformations in the tissue to contractile activity and polarization in the cells. A new ingredient of our model is a feedback between local strain, polarization, and contractility that naturally yields a mechanism for viscoelasticity and effective inertia in the cell monolayer. Using a combination of analytical and numerical techniques, we demonstrate that our model quantitatively reproduces many experimental findings [Nat. Phys. 8, 628 (2012)], including the buildup of intercellular stresses, and the existence of traveling mechanical waves guiding the oscillatory monolayer expansion.

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  • Received 8 November 2014

DOI:https://doi.org/10.1103/PhysRevLett.114.228101

© 2015 American Physical Society

Authors & Affiliations

Shiladitya Banerjee1,*,†, Kazage J. C. Utuje2, and M. Cristina Marchetti2,3,*,‡

  • 1James Franck Institute, The University of Chicago, Chicago, Illinois 60637, USA
  • 2Department of Physics, Syracuse University, Syracuse, New York 13244, USA
  • 3Syracuse Biomaterials Institute, Syracuse University, Syracuse, New York 13244, USA

  • *To whom correspondence may be addressed.
  • shiladityab@uchicago.edu
  • mcmarche@syr.edu

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Issue

Vol. 114, Iss. 22 — 5 June 2015

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