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Stress Clamp Experiments on Multicellular Tumor Spheroids

Fabien Montel, Morgan Delarue, Jens Elgeti, Laurent Malaquin, Markus Basan, Thomas Risler, Bernard Cabane, Danijela Vignjevic, Jacques Prost, Giovanni Cappello, and Jean-François Joanny
Phys. Rev. Lett. 107, 188102 – Published 24 October 2011
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Abstract

The precise role of the microenvironment on tumor growth is poorly understood. Whereas the tumor is in constant competition with the surrounding tissue, little is known about the mechanics of this interaction. Using a novel experimental procedure, we study quantitatively the effect of an applied mechanical stress on the long-term growth of a spheroid cell aggregate. We observe that a stress of 10 kPa is sufficient to drastically reduce growth by inhibition of cell proliferation mainly in the core of the spheroid. We compare the results to a simple numerical model developed to describe the role of mechanics in cancer progression.

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  • Received 3 March 2011

DOI:https://doi.org/10.1103/PhysRevLett.107.188102

© 2011 American Physical Society

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Forcing Tumor Arrest

Published 24 October 2011

Experiments on tumorlike collections of cells suggest that mechanical stress can play a role in limiting tumor growth.

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Authors & Affiliations

Fabien Montel1, Morgan Delarue1, Jens Elgeti1, Laurent Malaquin1, Markus Basan1, Thomas Risler1, Bernard Cabane3, Danijela Vignjevic2, Jacques Prost1,3, Giovanni Cappello1,*, and Jean-François Joanny1

  • 1UMR 168, Institut Curie, Centre de Recherche, 26 rue d’Ulm 75005 Paris, France
  • 2UMR 144, Institut Curie, Centre de Recherche, 26 rue d’Ulm 75005 Paris, France
  • 3ESPCI, 10 rue Vauquelin, 75005 Paris, France

  • *giovanni.cappello@curie.fr

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Issue

Vol. 107, Iss. 18 — 28 October 2011

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