Single-Molecule Rupture Dynamics on Multidimensional Landscapes

Yohichi Suzuki and Olga K. Dudko
Phys. Rev. Lett. 104, 048101 – Published 25 January 2010
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Abstract

We explore emergent effects of multidimensionality of the free energy landscape on single-molecule kinetics under constant force. The proposed minimal model reveals the existence of a spectrum of unusual scenarios for the force-dependent lifetime, all of which are shown to occur on a free energy landscape with a single transition state. We present an analytical solution that governs single-molecule responses to a constant force and relates them to microscopic parameters of the system.

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  • Received 27 August 2009

DOI:https://doi.org/10.1103/PhysRevLett.104.048101

©2010 American Physical Society

Authors & Affiliations

Yohichi Suzuki and Olga K. Dudko

  • Department of Physics and Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California 92093, USA

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Vol. 104, Iss. 4 — 29 January 2010

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