Point-Mutation Effects on Charge-Transport Properties of the Tumor-Suppressor Gene p53

Chi-Tin Shih, Stephan Roche, and Rudolf A. Römer
Phys. Rev. Lett. 100, 018105 – Published 8 January 2008

Abstract

We report on a theoretical study of point mutations effects on charge transfer properties in the DNA sequence of the tumor-suppressor p53 gene. On the basis of effective tight-binding models which simulate hole propagation along the DNA, a statistical analysis of mutation-induced charge transfer modifications is performed. In contrast to noncancerous mutations, mutation hot spots tend to result in significantly weaker changes of transmission properties. This suggests that charge transport could play a significant role for DNA-repairing deficiency yielding carcinogenesis.

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  • Received 23 August 2007

DOI:https://doi.org/10.1103/PhysRevLett.100.018105

©2008 American Physical Society

Authors & Affiliations

Chi-Tin Shih1, Stephan Roche2, and Rudolf A. Römer3

  • 1Department of Physics, Tunghai University, 40704 Taichung, Taiwan
  • 2CEA/DSM/DRFMC/SPSMS, 17 avenue des Martyrs, 38054 Grenoble, France
  • 3Department of Physics and Centre for Scientific Computing, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, United Kingdom

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Issue

Vol. 100, Iss. 1 — 11 January 2008

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