Abstract
RNA viruses mutate at a rate times faster than their DNA counterparts. This process can be simulated by a continuous stochastic model on a smooth one-dimensional fitness landscape where selection forces the viral quasispecies to climb uphill to higher fitness values. Theoretical results of the model with drift velocity proportional to fitness are fitted to the experimental observations made by Novella et al. [Proc. Natl. Acad. Sci. U.S.A. 92, 5841 (1995)].
- Received 1 August 1997
DOI:https://doi.org/10.1103/PhysRevE.57.2471
©1998 American Physical Society