Simulation of the differential adhesion driven rearrangement of biological cells

James A. Glazier and François Graner
Phys. Rev. E 47, 2128 – Published 1 March 1993
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Abstract

We show that differential adhesion with fluctuations is sufficient to explain a wide variety of cell re- arrangement, by using the extended large-Q Potts model with differential adhesivity to simulate different biological phenomena. Different values of relative surface energies correspond to different biological cases, including complete and partial cell sorting, checkerboard, position reversal, and dispersal. We examine the convergence and temperature dependence of the simulation and distinguish spontaneous, neutral, and activated processes by performing simulations at different temperatures. We discuss the biological and physical implications of our quantitative results.

  • Received 7 August 1992

DOI:https://doi.org/10.1103/PhysRevE.47.2128

©1993 American Physical Society

Authors & Affiliations

James A. Glazier and François Graner

  • Research Institute of Electrical Communication, Tohoku University, 2-1-1 Katahira, Sendai 980, Japan

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Vol. 47, Iss. 3 — March 1993

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